" New release: temporary price reduction"
One of the shortcommings of the current TCI systems is the lack of an universal model for Propofol: a model that is suitable for all type of patients in whome Propofol can be used. In the ideal world the anaesthesiologist should not have to worry about these models like he does not have to worry about the internal mechanical parts of for example his vaporiser. Unfortunately the ongoing debate about the model parameters, how to derive them and the unexpected effects of the extrapolation of these parameters outside the boundaries of
the original research has led to a confusing situation where only for propofol there are 5 commercially exploited models to choose from. Even one model has, with the same name, a different implementation in the commercially available TCI systems.
No model is perfect and this will most likely not be an exeption, but to have one model only is certainly an idea to go for. The authors of this model fulfilled an enormous task to incorporate all the available data. This is reflected in the complicated parameter description.
In the newest version of Tivatrainer (version 9 built 5)this model now is available. Also for TivatrainerX it will be soon available in the internet list. For the real Pk enthousiasts I develloped this tool so you can easily study the effect on the different Pk parameters. It is my limited contribution to the idea of developping an unified model. If you want to see the effect of these parameters on the dose concentration relationship I invite you to use Tivatrainer and TivatrainerX. Next step will have to be an apropriate clinical evaluation and development of a practical PD model. In the meanwhile using the IVassist mode from TivatrainerX you can already see how you possibly could adjust your dose using Pk principles even without TCI. But remember: always use your good clinical judgement and expertise.