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Name

Propofol

Description

Population[copy]

Author

White&Kenny

Publication

Clin Pharmacokinet 2008:47(2)

Drug Type

Hypnotics

Co-parameters

Gender,Age

Dilution (mg/ml)

Manual Bolus Units

mg/kg

Manual Rate Units

mg/kg/hr

Opioid Potency

-1.00

Limitations

{age<16|Age too low:<16}{ weight<30|weight too low:<30}

Kinetic Parameter Type

Rateconstants

 

 

VC

K12 or C2 or ThAlfa

0.112~/min

K21 or V2 or ThBheta

0.055

K13 or C3 or ThGamma

0.0419

K31 or V3 or Vdss

K10 or Clearance

{Female|(37.87-0.198*Age)/(191.8-0.67*Age)}{Male|(26.88-0.029*Age)/(175.5-0.046*Age)}~/Min

Thalf Keo

Effect label

Thalf Keo extra

Effect label extra

Cp low

Hint Cp low

Cp high

{age<12 | 7000}{Age>=65 | 3500}{5000}

Hint Cp high

Hint Area

Cp watch

Max Y

{Age<12 | 15000} {10000}

Decimals

Tick Y axis

1000

Max Y rate

1000

Concentration units

µg

Scaling factor

1000.00

Overshoot (Effect TCI)

Record edited by:

Frank Engbers

Version

1